Large-scale model quality assessment for improving protein tertiary structure prediction
نویسندگان
چکیده
منابع مشابه
Large-scale model quality assessment for improving protein tertiary structure prediction
MOTIVATION Sampling structural models and ranking them are the two major challenges of protein structure prediction. Traditional protein structure prediction methods generally use one or a few quality assessment (QA) methods to select the best-predicted models, which cannot consistently select relatively better models and rank a large number of models well. RESULTS Here, we develop a novel la...
متن کاملProtein structure prediction and model quality assessment.
Protein structures have proven to be a crucial piece of information for biomedical research. Of the millions of currently sequenced proteins only a small fraction is experimentally solved for structure and the only feasible way to bridge the gap between sequence and structure data is computational modeling. Half a century has passed since it was shown that the amino acid sequence of a protein d...
متن کاملLarge-scale structure prediction by improved contact predictions and model quality assessment
Motivation Accurate contact predictions can be used for predicting the structure of proteins. Until recently these methods were limited to very big protein families, decreasing their utility. However, recent progress by combining direct coupling analysis with machine learning methods has made it possible to predict accurate contact maps for smaller families. To what extent these predictions can...
متن کاملLiveBench-8: the large-scale, continuous assessment of automated protein structure prediction.
We present the results of the evaluation of the latest LiveBench-8 experiment. These results provide a snapshot view of the state of the art in automated protein structure prediction, just before the 2004 CAFASP-4/CASP-6 experiments begin. The last CAFASP/CASP experiments demonstrated that automated meta-predictors entail a significant advance in the field, already challenging most human expert...
متن کاملIn Silico Prediction and Docking of Tertiary Structure of Multifunctional Protein X of Hepatitis B Virus
Hepatitis B virus (HBV) infection is a universal health problem and may result into acute, fulminant, chronic hepatitis liver cirrhosis, or hepatocellular carcinoma. Sequence for protein X of HBV was retrieved from Uniprot database. ProtParam from ExPAsy server was used to investigate the physicochemical properties of the protein. Homology modeling was carried out using Phyre2 server, and refin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2015
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btv235